Again, I did a bit of research this morning, sorting through the endless array of drugs for depression. The most significant problem I face is my lack of energy, my difficulty just getting up and doing things.
My psychiatrist has been resistant to Provigil before, given my history of stimulant abuse. But I’ve done relatively well with Vyvanse. Provigil appears to be less addictive. Below is my notes on the drug. Yes, I used wikipedia, and I am not ashamed.
If you take Provigil, let me know your thoughts on it, I’d greatly appreciate it.
Off-label use for fatigue
- reported by some with multiple sclerosis.
- In 2000, Cephalon conducted a study to evaluate… A group of 72 people with MS… Participants taking a lower dose of modafinil reported feeling less fatigued and there was a statistically significant difference in fatigue scores for the lower dose versus the placebo. The higher dose of modafinil was not reported to be significantly more effective.
- Modafinil is also used off-label to treat sedation and fatigue in many conditions, including depression
Addiction and dependence potential
- addiction and dependence liabilities of modafinil are very low.
- shares biochemical mechanisms with addictive stimulant drugs, and some studies have reported it to have similar mood-elevating properties, although to a lesser degree.
- In accordance, although very rare, case reports of modafinil abuse exist.
- a schedule IV controlled substance, a category for drugs with valid medical uses and low but significant addiction potential.
- Adderall and Vyvanse have significant more abuse potential, schedule II
Large-scale clinical studies have found no evidence of tolerance with modafinil at therapeutic dosages even with prolonged use (for 40 weeks and as long as three years).